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CSF rhinorrhoea refers to the drainage of cerebrospinal fluid through the nose. Measures of CSF components such as glucose have been used in the past, but are neither sensitive nor specific; beta-2 transferrin, however, has been shown to have a high positive predictive value. It has also been noted to be characterized by unilateral discharge. It is a sign of basal skull fracture. Management includes watchful waiting - leaks often stop spontaneously; if this does not occur then neurosurgical closure is necessary to prevent the spread of infection to the meninges.〔 Other signs of basal skull fracture includes CSF otorrhoea (drainage of CSF through the ear). It can have devastating complications in some patients, as the communication between the nasal cavity and the cerebrospinal fluid and CNS can result in bacterial infections of the CNS that can have catastrophic effects on the patient.〔 CSF rhinorrhoea can also be a symptom of a pituitary adenoma. Historically this was sometimes referred to as "a gathering in the head"〔''The Homoeopathic Treatment of Surgical Diseases'', by G. Gilchrist, M. D., published by C. S. Halsey, 1873. http://archive.org/stream/homoeopathictrea00gilc/homoeopathictrea00gilc_djvu.txt〕 ==See also== *traumatic head injury *meningitis *cerebrospinal fluid *Beta-2 transferrin 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Cerebrospinal fluid rhinorrhoea」の詳細全文を読む スポンサード リンク
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